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RETINAL DEGENERATION

From Bench to Bedside

Friday, April 8th 2005

13:15 F. Badura, ProRetina Deutschland: Welcome remarks

13:25 Prof. E. Zrenner, Tübingen: “The development of research in hereditary retinal degeneration”

13:45 – 15:30 Session 1: The Functional Retina
Chairman: E. Zrenner

  1. M. Griffith: “The patient’s view”
  2. K.-W. Koch, Oldenburg: “Regulation of phototransduction”
  3. K. Rüther, Berlin: “The role of protein kinase C-alpha in the On-bipolar function”
  4. A. Reichenbach, Leipzig: “The role of the Müller (Glial) cell in retinal degeneration”
15:30 – 16:00 Coffee break

16:00 – 18:00 Session 2: Degeneration of photoreceptors and the retinal pigment epithelium – molecular mechanisms
Chairman: S. Bhattacharya

  1. D. Besch, Tübingen: “Dysfunction of the retinal pigment epithelium in inherited multifocal RPE diseases”
  2. C. Driessen, Nijmegen: “Ocular retinoid biochemistry and its role in human disease”
  3. B.Wissinger, Tübingen: “Pathomechanisms of cone photoreceptor function loss”
  4. B. Laggerbauer, Würzburg: “Genetic and biochemical analysis of RP-linked pre-mRNA splicing factors”

18:00 Dinner

19:15 Guest-Lecture: S. Bhattacharya, London: “The European dimension: Strategic approaches in retinal research”

19:45 – Open End: WIP (Work in Progress) – Session with ‚Smart and Easy Jazz’

Saturday, April 9th 2005

8:30 – 10:15 Session 3: The retinal proteome: new proteins – new views
Chairman: O. Strauss

  1. M. Ueffing, München: “Analysis of protein expression and signaling in the Mueller cell”
  2. J. Förster, Würzburg: “The MAGUK scaffolding proteins in the mammalian retina”
  3. J. H. Brandstätter, Erlangen: “The proteome of the photoreceptor synapse”
  4. U. Wolfrum, Mainz: “Molecular analyses of Usher 1 and 2 proteins in retinal photoreceptor cells”

10:15 Coffee break

10:45 – 12:30 Session 4: Animal models
Chairman: B.H.F. Weber

  1. E. Knust, Düsseldorf: “Drosophila crumbs – from epithelial cell polarity to retinal degeneration”
  2. U. Luhmann, Zürich: “Abnormal intraretinal vascular development and regression of hyaloid blood vessels in a knockout mouse model for Norrie disease/exudative vitreoretinopathy”
  3. M. W. Seeliger, Tübingen: “In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy”
  4. K. K. Singh, Hannover: “Genetics of retinal drusen formation in rhesus macaques”

12:30 Lunch

13:45 – 15:30 Session 5: Therapeutic strategies in hereditary retinal degeneration
Chairman: A. Laties

  1. A. Wenzel, Zürich: “Apoptosis in retinal degeneration-Neuroprotection of photoreceptors”
  2. B. Weber, Regensburg: “Rescue of photoreceptor degeneration in a genetic mouse model for X-linked juvenile retinoschisis”
  3. U. Bartsch, Hamburg: “Stem cell based therapeutic approaches”
  4. P. G. Layer, Darmstadt: “Reaggregates and stem cells for retinal tissue engineering”

15:30 Coffee break

16:00 – 17:00 Round Table Discussion

17:00 Farewell Remarks

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